- Clb5 Clb6 Mutants
- clb5∆ clb6∆
- TAB6-1 clb5∆ clb6∆
- cdc20∆ clb5∆
- cdc20∆ pds1∆ clb5∆
- CLB2-db∆ clb5∆
- CLB2-db∆ clb5∆ in galactose
- cln1∆ cln2∆ clb5∆ clb6∆
- CLB5-db∆
- CLB5-db∆ sic1∆
- CLB5-db∆ pds1∆
- CLB5-db∆ pds1∆ cdc20∆
- GAL-CLB5
- GAL-CLB5 cdh1∆
- GAL-CLB5 sic1∆
- GAL-CLB5-db∆
- cln1∆ cln2∆ cln3∆ multi-copy CLB5
- cln1∆ cln2∆ cln3∆ GAL-CLB5
GAL-CLB5 cdh1∆
debug: ,
test user =
test db =
Simulation:
Change of parameters: ksb5'=0.012, kscdh=0, MDT=150, init CDH1=CDH1T=0
Length of G1 phase: 126 min.
Mass at division: 1.36.
Experiments:
Chen, K.C., Calzone, L., Csikasz-Nagy, A., Cross, F.R., Novak, B. and Tyson, J.J. (2004). Integrative analysis of cell cycle control in budding yeast. Mol. Biol. Cell 15:3841-3862.
[Abstract] [Article]
[Abstract] [Article]
Experimental results: Inviable.
His observation: "Although the mutant is ultimately inviable or extremely slow-growing on galactose, this is not associated with any obvious problems in a short-term experiment. These cells clearly go through several doublings, probably without much difficulty, on galactose medium, and they remain reasonably viable when returned to glucose, like GAL-CLB5 cells. The DNA profile looks like that of GAL-CLB5 controls, mostly 2C DNA. So I think at the level of a computational model, it is not reasonable to expect the model to predict inviability of GAL-CLB5 cdh1∆ mutants. They should probably look pretty viable".